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papillary mesothelioma pathology outlines : Well differentiated papillary mesothelioma

papillary mesothelioma pathology outlines : Well differentiated papillary mesothelioma

Testis & epididymis

Paratesticular tumors

Well differentiated papillary mesothelioma

Author: Jennifer Gordetsky, M.D.

Editor-in-Chief: Debra L. Zynger, M.D.

Topic Completed: 1 November 2013

Minor changes: 19 January 2021

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: Benign mesothelioma [title] testis

Related topics: Malignant mesothelioma

Jennifer Gordetsky, M.D.

Page views in 2020: 2,251

Page views in 2021 to date: 774

Table of Contents

Definition / general | Epidemiology | Sites | Clinical features | Diagnosis | Case reports | Radiology images | Treatment | Microscopic (histologic) images | Cytology description | Positive stains | Negative stains | Electron microscopy description | Differential diagnosis | Additional references

Cite this page: Gordetsky J. Well differentiated papillary mesothelioma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/testismesothelioma.html. Accessed May 22nd, 2021.

Definition / general

Histologic variant of mesothelioma composed entirely of bland papillary structures and tubules with no identifiable invasion


  • Usually occurs in the peritoneum of young women
  • Few cases reported in the tunica vaginalis of the testis
  • Ages ranging from 18 to 69
  • Sites
  • Peritoneum and tunica vaginalis
  • Clinical features
  • Scrotal / peritesticular mass, associated with hydrocele
  • Diagnosis
  • Mesothelial origin can be confirmed by immunohistochemical stains

Case reports

18 year old man with hydrocele (J Clin Pathol 1992;45:1029)

35 year old man with bilateral hydroceles (Urol Oncol 2006;24:36)

48 year old man without asbestos exposure (Korean J Pathol 2014;48:225)

Radiology images

Scrotal ultrasound


  • Complete excision
  • Cytology description
  • Moderately cellular, uniform epithelioid cells arranged in papillary groups with fibrovascular cores
  • Cells have moderate cytoplasm, uniform round nuclei, distinct nucleoli
  • Minimal atypia
  • Few lymphocytes scattered in the background
  • No mitoses

Positive stains

AE1/3, CK7, WT1, CK5/6, calretinin, CAIX

Negative stains

p53 (may have focal positivity), CEA

Electron microscopy description

Tumor cells are round to polygonal in shape with numerous short and long slender microvilli on the free surfaces

Cytoplasmic organelles include moderate amounts of mitochondria, moderate amounts of rough endoplasmic reticulum, free ribosomes and microfilaments

  • Centrally located oval nuclei, euchromatin and prominent nucleoli
  • Well developed desmosomes (Pathol Res Pract 2010;206:105)
  • Differential diagnosis
  • Malignant mesothelioma
  • Papillary carcinoma
  • Reactive mesothelial hyperplasia

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